KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
20.61
Human Site:
T719
Identified Species:
45.33
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
T719
D
E
R
L
Q
G
E
T
L
D
Q
Q
L
G
R
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
T719
D
E
R
L
Q
G
E
T
L
D
Q
Q
L
G
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
T720
D
E
R
L
Q
E
E
T
L
D
Q
Q
L
G
R
Rat
Rattus norvegicus
Q6T3U3
1331
146397
Q731
L
P
R
M
P
G
E
Q
R
E
A
H
I
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
T703
D
E
R
L
E
G
E
T
L
D
K
Q
I
G
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
A635
S
S
F
S
E
T
V
A
F
F
L
G
A
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
T721
D
Q
R
K
P
N
E
T
L
E
Q
Q
V
G
R
Honey Bee
Apis mellifera
XP_624752
1358
152373
S713
E
S
R
R
P
N
E
S
I
P
E
H
I
G
R
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
Q734
M
P
Y
M
S
P
D
Q
C
P
E
I
V
G
M
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
N759
D
E
R
Y
P
H
E
N
R
A
E
H
I
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
Y640
I
F
L
I
T
H
E
Y
D
R
N
C
E
Q
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
93.3
33.3
N.A.
N.A.
80
N.A.
0
N.A.
60
26.6
6.6
40
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
93.3
53.3
N.A.
N.A.
100
N.A.
6.6
N.A.
80
60
33.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
10
10
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% C
% Asp:
55
0
0
0
0
0
10
0
10
37
0
0
0
0
0
% D
% Glu:
10
46
0
0
19
10
82
0
0
19
28
0
10
0
0
% E
% Phe:
0
10
10
0
0
0
0
0
10
10
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
37
0
0
0
0
0
10
0
82
0
% G
% His:
0
0
0
0
0
19
0
0
0
0
0
28
0
0
0
% H
% Ile:
10
0
0
10
0
0
0
0
10
0
0
10
37
0
0
% I
% Lys:
0
0
0
10
0
0
0
0
0
0
10
0
0
0
10
% K
% Leu:
10
0
10
37
0
0
0
0
46
0
10
0
28
10
0
% L
% Met:
10
0
0
19
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
19
0
10
0
0
10
0
0
0
0
% N
% Pro:
0
19
0
0
37
10
0
0
0
19
0
0
0
0
0
% P
% Gln:
0
10
0
0
28
0
0
19
0
0
37
46
0
10
0
% Q
% Arg:
0
0
73
10
0
0
0
0
19
10
0
0
0
0
73
% R
% Ser:
10
19
0
10
10
0
0
10
0
0
0
0
0
0
10
% S
% Thr:
0
0
0
0
10
10
0
46
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
10
0
0
0
0
0
19
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
10
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _